Use Of Cholesterol Drugs By Patients Without High Cholesterol Level – Part 1 of 3
Use Of Cholesterol Drugs By Patients Without High Cholesterol Level. When the US Food and Drug Administration in February 2010 approved the use of the cholesterol-lowering statin tranquillizer Crestor for some nation with normal cholesterol levels, cardiologist Dr Steven E Nissen cheered the decision. “You have to go with the scientific evidence,” said Nissen, who is chairman of cardiovascular cure-all at the Cleveland Clinic. “A clinical trial was done and there was a substantial reduction in morbidity and mortality in people treated with this drug”.
But Dr Mark A Hlatky, a professor of trim research and policy and medicine at Stanford University, has expressed doubts about the FDA move. He worries that more people will rely on a pill rather than diet and exercise to cut their heart risk, and also points to studies linking statins such as Crestor to muscle troubles and even diabetes. “I haven’t seen anything that changes my thinking about that”.
So, will millions of healthy Americans soon join the millions of less-than-healthy commonalty who already take these blockbuster drugs? The FDA’s Feb 9 approval of expanded use of rosuvastatin (Crestor) was based on results of the JUPITER study, which involved more than 18000 people and was financed by the drug’s maker, AstraZeneca. People in the headache who took the drug for an average of 1,9 years had a 44 percent lower risk of heart attack, stroke and other cardiovascular problems compared to those who took a placebo – results so superior that the trial was cut short. Based on JUPITER, an FDA advisory committee voted 12 to 4 in December to approve widened use of the drug.
The populate in the trial included men over 50 and women over 60 with normal or near-normal cholesterol levels. However, these individuals did have high levels of C-reactive protein, a marker of inflammation that has also been linked to cardiovascular problems. They also had at least one other determination risk factor, such as obesity or high blood pressure.
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